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Related Concept Videos

Stress01:20

Stress

8.1K
When a force is applied on a body, it undergoes deformation. In order to restore the body to its original shape and/or size, an opposite or restoring force is generated within the body. This restoring force is equal to the magnitude of the applied force, but acts in the opposite direction. The amount of this restoring force developed per unit area of the body is called stress. Stress is a tensor quantity and has the SI unit pascal. Stress can be separated into four broad categories depending...
8.1K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

107
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
107
Stress Response System01:21

Stress Response System

401
The stress response system, also known as the fight-or-flight response, is the body's automatic physiological reaction to perceived threats. Hans Selye introduced the concept of General Adaptation Syndrome (GAS) to describe the predictable pattern of changes that occur in response to stress. GAS consists of three sequential stages: alarm, resistance, and exhaustion. This model helps explain how chronic stress can contribute to health problems.
Alarm stage
In the alarm stage, the body's...
401
Physiological Foundation of Stress01:24

Physiological Foundation of Stress

242
Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...
242
Components of Stress01:23

Components of Stress

338
Stress analysis under multiple loading conditions is intricate, necessitating a comprehensive grasp of normal and shearing stresses. Consider a small cube at point O, subjected to stress on all six faces, visible or not. Normal stress components σx, σy, σz act perpendicularly to the x, y, and z axes. Shearing stress components τxy and τxz are exerted on faces perpendicular to these axes.
Interestingly, the hidden cube faces also experience these stresses, equal and...
338
Stress and Mental Health01:30

Stress and Mental Health

298
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
298

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Author Spotlight: Exploring the Role of Unfolded Protein Response in HIV-1 Replication and Infectivity
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COVID-19 and Cell Stress.

Abdo A Elfiky1, Ibrahim M Ibrahim2, Fatma G Amin3

  • 1Biophysics Department, Faculty of Science, Cairo University, Giza, Egypt. abdo@sci.cu.edu.eg.

Advances in Experimental Medicine and Biology
|May 11, 2021
PubMed
Summary
This summary is machine-generated.

The COVID-19 pandemic highlights the need to understand virus-induced pneumonia. Cell stress mechanisms, particularly Heat Shock Protein 5A (HSP5A), offer potential therapeutic targets against SARS-CoV-2 infection and related complications.

Keywords:
COVID-19Cell stressChaperoneGRP78SARS-CoV-2Spike

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Area of Science:

  • Virology
  • Cell Biology
  • Immunology

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, presents a significant global health challenge.
  • Understanding COVID-19-induced pneumonia is crucial for managing associated health complications.
  • Cell stress is a known factor in infections and cancer, involving key regulatory proteins.

Purpose of the Study:

  • To review current knowledge on SARS-CoV-2 and its impact on cellular mechanisms.
  • To explore the role of cell stress pathways in viral infections.
  • To identify potential therapeutic strategies targeting cell stress responses against COVID-19.

Main Methods:

  • Literature review of existing research on SARS-CoV-2.
  • Analysis of cell stress mechanisms and their involvement in viral pathogenesis.
  • Examination of Heat Shock Proteins (HSPs) as potential therapeutic targets.

Main Results:

  • Upregulation of Heat Shock Protein 5A (HSP5A), also known as GRP78 or Bip, is observed in various viral infections.
  • HSP families are critical for cellular response to stress and normal cellular functions.
  • Targeting HSPs may offer a strategy to inhibit viral replication and mitigate disease severity.

Conclusions:

  • Cell stress, particularly mediated by HSP5A, is implicated in SARS-CoV-2 infection.
  • HSP5A represents a promising target for developing novel antiviral therapies against COVID-19.
  • Further research into cell stress pathways could yield effective strategies to combat the pandemic.