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Therapeutic Development in COVID-19

Chan Yang1, Yuan Huang1, Shuwen Liu2,3,4

  • 1Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.

Advances in Experimental Medicine and Biology
|May 11, 2021
PubMed

Insights

Scientists are exploring antiviral drugs and immune support for coronavirus disease 2019 (COVID-19) treatment. This review summarizes current therapies and offers insights for future COVID-19 management strategies.

Area of Science:

  • Virology
  • Infectious Diseases
  • Clinical Pharmacology

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, has profoundly impacted global health and economies.
  • Diverse clinical presentations of COVID-19 complicate treatment, with no standard antiviral regimen established beyond supportive care.
  • Extensive research is ongoing to identify effective antiviral drugs and vaccines for COVID-19 prevention and treatment.

Purpose of the Study:

  • To summarize current antiviral and adjuvant therapies used in clinical practice for COVID-19.
  • To provide a theoretical foundation for the future development of COVID-19 treatments.
  • To review ongoing clinical trials evaluating novel therapeutic strategies.

Main Methods:

  • Review of current clinical practices for COVID-19 treatment.
  • Analysis of ongoing clinical trials for antiviral and immunomodulatory drugs.
  • Synthesis of existing literature on SARS-CoV-2 therapeutics.

Main Results:

  • No definitive antiviral regimen beyond supportive therapy is currently established for COVID-19.
  • Clinical trials are actively investigating drugs targeting viral replication and immune enhancement.
  • A range of antiviral and adjuvant therapies are under evaluation for efficacy.

Conclusions:

  • Current COVID-19 treatment relies heavily on supportive care due to the lack of a standard antiviral regimen.
  • Future treatment strategies will likely involve a combination of antivirals and immune-modulating therapies.
  • Continued research and clinical trials are crucial for establishing effective COVID-19 management protocols.
Keywords:
AntiviralCOVID-19DrugsSARS-CoV-2Therapy

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