Mixed functionalization strategy on indium-organic framework for multiple ion detection and H₂O₂ turn-on sensing

Area of Science:

• Materials Science
• Analytical Chemistry
• Nanotechnology

Background:

• Metal-organic frameworks (MOFs) offer tunable properties for sensing applications.
• Functionalization of MOFs enhances their detection capabilities.
• Developing selective and sensitive probes for environmental and biological analytes is crucial.

Purpose of the Study:

• To introduce a novel amino-functionalized 3D indium MOF (In1-NH2) for improved fluorescence detection.
• To establish a mixed-functionalization strategy for detecting heavy metal ions, anions, and small molecules.
• To develop a post-synthetically modified MOF (PBA-In1) for sensitive hydrogen peroxide detection.

Main Methods:

• Synthesis of a novel amino-functionalized 3D indium MOF, [In(BDC-NH2)(OH)]n (In1-NH2).
• Utilizing a mixed-functionalization strategy for simultaneous detection.
• Employing post-synthetic modification to introduce boronic acid groups for enhanced sensing.
• Characterizing the fluorescence detection performance for various analytes.

Main Results:

• In1-NH2 demonstrated excellent fluorescence and highly sensitive detection of Fe3+, Cu2+, Pb2+, and ClO- in water.
• The modified PBA-In1 exhibited efficient sensing of hydrogen peroxide with a low limit of detection (0.42 μM).
• The functionalized MOF platform showed broad linear ranges and short response times for detected analytes.

Conclusions:

• The developed amino-functionalized MOF (In1-NH2) is effective for multiple ion detection.
• The boronic acid-functionalized MOF (PBA-In1) shows significant potential as a probe for hydrogen peroxide and metabolite monitoring in biochemical research.
• This functionalization platform offers a versatile tool for enhancing MOF-based fluorescence detection.