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Updated: Nov 6, 2025
Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Platinum(II) Metallatriangle: Construction, Coassembly with Polypeptide, and Application in Combined Cancer
Yue Zhang1, Xin Yan1, Ling Shi1
1School of Chemistry and Chemical Engineering, Nantong University, Nantong, Jiangsu 226019, P.R. China.
Abstract:
The development of the supramolecular coordination complex with different shapes and dimensionalities lays the basis for its application in different areas. In this study, a porphyrin-based 3D organo-Pt(II) metallatriangle (MTA) was fabricated through the reported method termed as "coordination driven self-assembly". 31P NMR, 1H NMR, HR-MS, and theoretical calculation were employed to characterize the resultant MTA fully. Furthermore, the fabricated nanocomposite through coassembly of MTA and an amphiphilic polypeptide (PEG-PPT) could generate singlet oxygen (1O2) under the NIR irradiation and release a Pt drug under a low-pH microenvironment. 1O2 and the Pt drug can both damage the cancer cells, which improves the efficiency of cancer therapies. The fabrication of a Pt-porphyrin metallatriangle expands the topological structures, and the Pt-porphyrin metallatriangle can be applied to the combined cancer therapies. Moreover, various stimuli-responsive groups can be modified to the triangle, so a new method is created to develop high-performance biosupramolecular materials.
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