Does COVID-19 infection influence patients' performance during IVF-ET cycle?: an observational study
Raoul Orvieto1,2,3, Aliza Segev-Zahav1,2, Adva Aizer1,2
1Department of Obstetrics and Gynecology, Chaim Sheba Medical Center (Tel Hashomer), Ramat Gan, Israel.
Summary
Coronavirus disease 19 (COVID-19) infection did not impact ovarian stimulation or embryological variables in subsequent in vitro fertilization (IVF) cycles. However, a lower proportion of top-quality embryos were observed post-infection.
Area of Science:
- Reproductive Endocrinology
- Infectious Diseases
- In Vitro Fertilization
Background:
- Limited data exists on the impact of coronavirus disease 19 (COVID-19) on subsequent in vitro fertilization (IVF) cycles.
- Understanding this impact is crucial for fertility treatment planning post-infection.
Purpose of the Study:
- To assess the influence of COVID-19 infection on IVF treatment outcomes.
- To compare ovarian stimulation and embryological variables before and after COVID-19 recovery.
Main Methods:
- Observational study conducted at a tertiary university-affiliated medical center.
- Compared IVF cycles of couples before and after the female or male partner recovered from COVID-19.
- Assessed ovarian stimulation and embryological variables, including top-quality embryo rates.
Main Results:
- Nine couples underwent IVF 8-92 days after COVID-19 recovery.
- No significant differences were observed in ovarian stimulation or general embryological variables.
- A significantly lower proportion of top-quality embryos was noted after COVID-19 infection.
Conclusions:
- COVID-19 infection did not affect ovarian reserve or patient performance in the immediate subsequent IVF cycle.
- A reduction in top-quality embryos suggests a potential impact on gamete quality.
- Postponing IVF treatment for at least 3 months after COVID-19 recovery is suggested to ensure gamete health.
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