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Subacute Thyroiditis in COVID-19 Patients
Ali Seyed Resuli1, Muzaffer Bezgal2
1Faculty of Medicine, Department of ENT, 209002İstanbul Yeni Yüzyıl University, İstanbul, Turkey.
Ear, Nose, & Throat Journal
|May 11, 2021
Summary
COVID-19 infection can affect the endocrine system, triggering subacute thyroiditis (SAT). Neck pain and odynophagia were the primary symptoms in patients with SAT following SARS-CoV-2 infection.
Area of Science:
- Endocrinology
- Infectious Diseases
- Otorhinolaryngology
Background:
- The COVID-19 pandemic, caused by SARS-CoV-2, has demonstrated multi-organ effects beyond respiratory illness.
- Emerging evidence suggests potential impacts on the endocrine system.
Purpose of the Study:
- To investigate the association between COVID-19 infection and the development of subacute thyroiditis (SAT).
- To identify clinical and diagnostic features of SAT in the context of acute SARS-CoV-2 infection.
Main Methods:
- Retrospective analysis of 5 patients presenting with neck pain and odynophagia.
- Included ENT examination, COVID-19 PCR testing, routine blood work, thyroid function tests (T3, T4, TSH), autoantibody levels (anti-TG, anti-TPO), thyroid scintigraphy, and ultrasonography.
Main Results:
- All 5 patients were female (average age 30.4 years) with no prior history of thyroiditis.
- All patients tested positive for COVID-19 via PCR.
- Key symptoms were odynophagia and neck pain, with no other typical COVID-19 signs.
Conclusions:
- SARS-CoV-2 infection is linked to thyroid dysfunction and can precipitate subacute thyroiditis.
- Neck pain and odynophagia are significant presenting symptoms of COVID-19-associated SAT.
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