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Architecture and assembly dynamics of the essential mitochondrial chaperone complex TIM9·10·12

Katharina Weinhäupl1, Yong Wang2, Audrey Hessel1

  • 1Univ. Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale (IBS), 71, Avenue Des Martyrs, 38044 Grenoble, France.

Structure (London, England : 1993)
|May 11, 2021
PubMed
Summary

Mitochondrial Tim chaperones, TIM9·10 and TIM9·10·12, dynamically exchange subunits. This dynamic equilibrium, with a 2:3:1 Tim9:Tim10:Tim12 stoichiometry, allows mitochondria to regulate inter-membrane space chaperone levels.

Keywords:
NMR spectroscopyTIM9·10TIM9·10·12kineticsmitochondrial biogenesismolecular dynamics simulationsprotein importreal-time NMRsmall-angle X-ray scatteringsubunit exchange

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