Selective adsorption of flavonoids on cerium-doped ferroferric oxide magnetic particles

Ce-doped Fe₃O₄ magnetic particles (Ce-Fe₃O₄ MPs) were synthesized by co-precipitation method. The coordination and adsorption properties of Ce-Fe₃O₄ MPs to different natural products were investigated. The results verified that the "catechol-like","maltol-like" and "acetylacetone-like" donor sets of flavonoids were the binding sites with Ce-Fe₃O₄ MPs. The adsorption was conformed to be pseudo-second-order model and single-layer adsorption after being characterized by adsorption kinetics and adsorption thermodynamics. The adsorption and desorption conditions were optimized. It was found that different components adsorbed on the Ce-Fe₃O₄ MPs surface can be selective desorbed in different solvents, which was helpful for the selective separation to adsorbed components. The Ce-Fe₃O₄ MPs were successfully applied to selective adsorption of compounds containing "catechol-like", "maltol-like" and "acetylacetone-like" donor sets in the crude extract of Scutellaria baicalensis Georgi and Rheum palmatum L. The results demonstrated that the magnetic solid phase extraction (MSPE) method based on Ce-Fe₃O₄ MPs has the advantages of high structural selectivity, high efficiency and low consumption, and can be used for efficient separation of flavonoids with specific structures from natural products.