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Cerebral Venous Thrombosis Associated with COVID-19 Infection: An Observational, Multicenter Study

Sajid Hameed1, Mohammad Wasay1, Bashir A Soomro2

  • 1Department of Medicine, Aga Khan University, Karachi, Pakistan.

Cerebrovascular Diseases Extra
|May 11, 2021
PubMed

Insights

Cerebral venous thrombosis (CVT) is more common in males with COVID-19. While mortality is high, survivors of COVID-19-related CVT often experience good neurological recovery.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Vascular Medicine

Background:

  • Coronavirus disease 2019 (COVID-19) is associated with hypercoagulability and thromboembolism.
  • Cerebral venous thrombosis (CVT) has been reported in COVID-19 patients.

Purpose of the Study:

  • To identify risk factors for CVT in COVID-19 patients.
  • To describe the presentation and outcomes of CVT in COVID-19 patients.

Main Methods:

  • Multicenter, multinational observational study.
  • Included adult patients (>18 years) with symptomatic CVT and recent COVID-19 infection.

Main Results:

  • Twenty male patients (mean age 42.4 years) with CVT and COVID-19 were included.
  • Headache and seizures were common symptoms; CVT presented early in 65% of cases.
  • Superior sagittal sinus thrombosis was most common; elevated D-dimer and inflammatory markers were frequent. Mortality was 20%, but survivors had good functional outcomes.

Conclusions:

  • COVID-19-related CVT affects males more frequently and at older ages than non-COVID-19 CVT.
  • Suspect CVT in COVID-19 patients with headache or seizures.
  • Despite high mortality, survivors of COVID-19-related CVT show good neurological recovery.
Abstract

Keywords:
COVID-19Cerebral venous thrombosisCoagulopathyHemorrhageStroke

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