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Related Experiment Videos

ST-segment fluctuation during treadmill exercise in patients with angina pectoris.

H Asanoi1, M Kuboki, M Yamamoto

  • 1Cardiovascular Institute, Tokyo, Japan.

Journal of Electrocardiology
|April 1, 1988
PubMed
Summary

Transient ST-segment fluctuations during exercise tests may indicate coronary artery vasospasms. Propranolol exacerbated these fluctuations in patients with angina pectoris, suggesting a link to vasospasm.

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Area of Science:

  • Cardiology
  • Exercise Physiology

Background:

  • ST-segment fluctuation during treadmill exercise is observed in some angina pectoris patients.
  • The study investigated the incidence and clinical significance of ST-segment fluctuation before and after propranolol administration.

Observation:

  • A significant ST-segment fluctuation (>0.5 mm upward shift) was assessed during graded treadmill tests.
  • Fluctuation incidence increased post-propranolol in patients with rest or rest/effort angina.
  • Minimal fluctuation occurred in patients with effort angina alone after propranolol.

Findings:

  • ST-segment fluctuation post-propranolol was noted in 14/30 patients with rest/effort angina versus 1/22 with effort angina alone.
  • Among 15 patients with fluctuation post-propranolol, coronary arteriography showed no significant stenosis in 7, one-vessel disease in 6, and two-vessel disease in 2.

Related Experiment Videos

  • ST-segment fluctuation was induced in 54% of patients with coronary artery spasm after propranolol, compared to 8% before.

    • Implications:

    • ST-segment fluctuation during exercise may be associated with transient coronary vasospasms.
    • Propranolol may exacerbate these vasospasms, highlighting its potential role in unmasking coronary artery spasm.
    • This finding suggests a diagnostic utility for monitoring ST-segment changes post-beta-blocker administration in specific patient groups.