Effect of acute hypertension on the cardiac rhythm. Experimental observations

An acute increase in blood pressure (BP) may be associated with the genesis of ventricular ectopy. Fourteen anesthetized dogs were examined to find out whether the critical pressure that causes an arrhythmia may be an index of the tendency of the myocardium to generate ectopic rhythms. An acute change in BP was produced 321 times using an arterial pressure reservoir or aortic obstruction or a metaraminol infusion or, inversely, arterial bleeding. Each time the BP was increased, cardiac arrhythmias appeared and each time the BP was decreased the cardiac arrhythmias disappeared. The most common type of arrhythmia was ventricular ectopy (123/167 acute BP increases), usually in a form of bigeminy. The next most common rhythm disturbance was atrioventricular block (32/167 acute BP increases), especially when a constant rate was achieved by atrial pacing. The BP above which an arrhythmia appeared varied greatly among different animals (189.0 +/- 55.1 mmHg, means +/- SD). It was significantly (p less than 0.01) reduced (-29.0 +/- 17.1 mmHg) following coronary ligation and significantly (p less than 0.05) raised (+/- 41.6 +/- 38.7 mmHg) following lidocaine administration. The incidence of ventricular ectopy on increasing the BP was significantly higher at low heart rates in ten experiments, lower in two and not significantly different in 14. The incidence of premature ventricular complexes, the degree of atrioventricular block and the PR interval in first-degree atrioventricular block, whenever these rhythm disorders appeared, were a function of the BP level. It is concluded that an acute increase in BP may cause rhythm disturbances, usually in the form of ventricular ectopy and/or atrioventricular block.(ABSTRACT TRUNCATED AT 250 WORDS)