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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
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Advancements in biomarkers for cardiovascular disease: diagnosis, prognosis, and therapy

Nicholas Wettersten1,2, Yu Horiuchi3, Alan Maisel2

  • 1Division of Cardiology, Veterans Affairs Medical Center, San Diego, CA, USA.

Faculty Reviews
|May 12, 2021
PubMed

Insights

Cardiology biomarkers like troponin and natriuretic peptides aid in diagnosing and treating heart conditions. New biomarkers for fibrosis, metabolism, and inflammation are expanding clinical applications in cardiovascular disease.

Area of Science:

  • Cardiology
  • Biomarker Discovery
  • Clinical Diagnostics

Background:

  • Biomarkers are crucial in cardiology for diagnosis, prognosis, and therapy guidance.
  • Established biomarkers like troponin and natriuretic peptides have been used for nearly two decades.
  • Their clinical applications continue to evolve beyond initial roles.

Purpose of the Study:

  • To review recent advancements in cardiovascular biomarkers.
  • To highlight the expanding utility of both established and novel biomarkers.
  • To discuss the integration of new biomarkers into clinical practice.

Main Methods:

  • Literature review of recent studies on cardiovascular biomarkers.
  • Analysis of established and emerging biomarker applications.
  • Synthesis of current trends in biomarker-guided cardiovascular care.

Main Results:

  • Significant advancements in the use of established biomarkers.
  • Discovery and validation of new biomarkers (e.g., soluble suppression of tumorigenicity 2, galectin 3).
  • Emerging roles for biomarkers of fibrosis, metabolism, and inflammation in cardiovascular disease.

Conclusions:

  • Cardiovascular biomarker field is rapidly evolving.
  • Continuous expansion of biomarker applications in clinical cardiology.
  • New biomarkers offer enhanced diagnostic and prognostic capabilities for cardiovascular diseases.

Keywords:
Biomarkersacute coronary syndromeheart failureprevention

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