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Related Experiment Videos

Etomidate in a new solvent. A clinical evaluation.

J G Hendry, B M Miller, N W Lees

    Anaesthesia
    |November 1, 1977
    PubMed
    Summary
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    Polyethylene glycol as a solvent for etomidate significantly reduces injection pain. This new formulation maintains etomidate's benefits, including cardiovascular stability and quick patient recovery.

    Area of Science:

    • Anesthesiology
    • Pharmacology

    Background:

    • Etomidate is an anesthetic agent known for its cardiovascular stability.
    • Pain on injection is a common and undesirable side effect of etomidate administration.

    Purpose of the Study:

    • To evaluate the efficacy of polyethylene glycol as a solvent for etomidate.
    • To determine if polyethylene glycol reduces pain on injection while preserving etomidate's clinical benefits.

    Main Methods:

    • Investigated the use of polyethylene glycol as a solvent for etomidate.
    • Assessed the incidence of pain on injection.
    • Monitored cardiovascular stability and recovery times.

    Main Results:

    • Polyethylene glycol significantly reduced the incidence of pain on injection compared to conventional solvents.

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  • Cardiovascular stability was maintained.
  • Rapid recovery was observed, consistent with previous findings.

    • Conclusions:

    • Polyethylene glycol is a promising solvent for etomidate, effectively mitigating injection pain.
    • This formulation offers a favorable safety and efficacy profile for etomidate administration.