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Updated: Nov 6, 2025

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
Theoretical considerations for a left atrial pump in heart failure with preserved ejection fraction
Hannah Rosenblum1, Michael Brener2, Daniel Burkhoff3
1Division of Cardiology, Department of Medicine Columbia University Irving Medical Center-NYP Hospital, New York, NY, USA. hr2270@cumc.columbia.edu.
Abstract:
Heart failure with preserved ejection fraction (HFpEF) is a heterogenous group of disorders, unified by findings of elevated left atrial and left ventricular filling pressures in the setting of normal systolic function. Medical therapies for HFpEF patients are markedly limited, and these patients are often unable to tolerate conventional left ventricular assist device therapies because of small chamber size. The Synergy System (CircuLite, Inc., Saddle Brook, NJ) was a micropump-based form of mechanical circulatory support in which flow derived from the left atrium was delivered to the subclavian artery. In this review, we discuss the potential role of the Synergy left atrial pump to address the hemodynamic derangements of HFpEF.
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