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Published on: July 4, 2021
Characteristics of cerebral sinus venous thrombosis in men
Naaem Simaan1, Andrei Filioglo1, Asaf Honig1
1Departments of Neurology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Insights
Cerebral sinus venous thrombosis (CSVT) affects men differently than women. Younger men show higher rates of Behcet's disease, while older men have more malignancies as CSVT causes.
Area of Science:
- Neurology
- Vascular Medicine
- Stroke Research
Background:
- Cerebral sinus venous thrombosis (CSVT) is a rare stroke subtype.
- CSVT is more prevalent in women, but male-specific data are limited.
Purpose of the Study:
- To investigate male-specific characteristics and risk factors in cerebral sinus venous thrombosis.
- To compare CSVT presentation and outcomes between male and female patients.
Main Methods:
- Retrospective analysis of consecutive CSVT patients (2005-2020).
- Comparison of demographics, clinical presentation, and outcomes between sexes.
- Subgroup analysis of male patients based on age (<35 vs. >35 years).
Main Results:
- Males constituted 31.3% of 150 CSVT patients.
- Males exhibited higher rates of prior thrombotic events, malignancies, and Behcet's disease.
- Malignancies were more common in older males; Behcet's disease in younger males.
Conclusions:
- Significant sex-specific differences exist in CSVT risk factors.
- Behcet's disease is a key factor in younger males with CSVT.
- Malignancies are primary drivers of CSVT in older males.
Objectives:
Cerebral sinus venous thrombosis (CSVT) is a rare stroke subtype that is more common in women, yet data regarding sex-specific characteristics are sparse. We aimed to study male-specific characteristics among patients with CSVT.
Materials & Methods:
Data of consecutive patients with CSVT, admitted to a single medical centre between 2005 and 2020, were retrospectively studied. Demographics, clinical presentations, radiological and outcome parameters were compared between male and female patients. Male patients were further divided into older and younger than 35 years old for additional comparisons.
Results:
Out of 15,224 patients diagnosed with stroke, 150 patients (1%) presented with CSVT and 47 (31.3%) of them were males. Males had significantly higher rates of previous thrombotic events (22% vs. 7%, p = .009), malignancies (32% vs. 16%, p = .022) and Behcet's disease (22% vs. 2%, p < .001). Additionally, we found that malignancies were significantly more prevalent in older males (48% vs. 17%, p = .022), while Behcet's disease was more often found in younger patients (35% vs. 9%, p = .032). Additional age-related differences in disease characteristics among male patients included a higher frequencies of papilledema (42% vs. 13%, p = .028), and cortical vein thromboses (21% vs. 0% p = .021) observed in the younger men.
Conclusions:
There are important differences in risk factors for thrombosis between men and women with CSVT. Behcet's disease is common in younger men, while malignancies are major causes of CSVT in older men.
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