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Updated: Nov 6, 2025

Effect of Artificial Tear Formulations on the Metabolic Activity of Human Corneal Epithelial Cells after Exposure to Desiccation
Published on: May 2, 2020
A new era of moisturizers
Neha Chandan1, Jeffrey R Rajkumar1, Vivian Y Shi2
1University of Illinois College of Medicine, Chicago, IL, USA.
Modern moisturizers with bioactive ingredients help repair skin barrier dysfunction. These advanced formulations target lipid imbalance, inflammation, and microbial issues for improved skin health, especially in atopic dermatitis.
Area of Science:
- Dermatology
- Biochemistry
- Microbiology
Background:
- Traditional moisturizers replenish skin lipids and hydration, reducing water loss.
- Epidermal lipid imbalance is a key factor in atopic dermatitis.
- Bioactive ingredients offer enhanced barrier repair and function.
Purpose of the Study:
- To review the use of modern moisturizers in skin barrier repair.
- To explore targeting skin barrier components, immune response, and microbial balance.
- To examine the role of bioactive ingredients in improving skin conditions.
Main Methods:
- A comprehensive narrative review of the literature.
- Searched MEDLINE and PubMed for relevant studies.
- Included English-language articles on moisturizers with specific bioactive agents.
Main Results:
- Bioactive ingredients upregulate lipid synthesis and reduce itch signals.
- These agents decrease inflammation, oxidative stress, and modulate skin microbiota.
- A shift to bioactive moisturizers offers new therapeutic options for barrier-defective skin.
Conclusions:
- Targeting the disrupted skin barrier is crucial for prevention and treatment.
- A combined strategy using various agents addresses barrier dysfunction effectively.
- This approach holds significant promise for clinical impact in dermatology.
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