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A nano-integrated microfluidic biochip for enzyme-based point-of-care detection of creatinine
Jianyong Li1, Zhenhua Li1, Yanzhi Dou1
1Division of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, P. R. China. songshiping@sinap.ac.cn wanglihua@sinap.ac.cn and University of Chinese Academy of Sciences, Beijing 100049, P. R. China.
Abstract:
A nano-integrated portable enzymatic microfluidic electrochemical biochip was developed for single-step point-of-care testing of creatinine. The biochip could automatically eliminate a lot of interferences from practical biological samples and enzymatic intermediate products. Gold nanostructure- and carbon nanotube-based screen-printed carbon electrodes were integrated into microfluidic structures to improve the detection performance for creatinine. The microfluidic electrochemical biochip holds promise to become a practical device for medical diagnosis, especially POCT.
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