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Updated: Nov 6, 2025
08:11
Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.
Published on: September 1, 2015
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Glycodendritic structures as DC-SIGN binders to inhibit viral infections
Javier Ramos-Soriano1, Javier Rojo1
1Glycosystems Laboratory, Instituto de Investigaciones Químicas (IIQ), Centro de Investigaciones Científicas Isla de La Cartuja, CSIC and Universidad de Sevilla, Américo Vespucio, 49, 41092 Sevilla, Spain. javier.rojo@iiq.csic.es.
Chemical Communications (Cambridge, England)
|May 12, 2021
Summary
Dendritic cell-specific intercellular adhesion molecule-3 grabbing non-integrin (DC-SIGN) is crucial for innate immunity and antiviral drug development. This review highlights carbohydrate multivalent systems targeting DC-SIGN to combat pathogen infections.
Area of Science:
- Immunology
- Virology
- Carbohydrate Chemistry
Background:
- Dendritic cell-specific intercellular adhesion molecule-3 grabbing non-integrin (DC-SIGN) is a key innate immune receptor.
- DC-SIGN mediates the infection process of various pathogens, making it an important drug target.
Purpose of the Study:
- To review the role of DC-SIGN in innate immunity and its significance in antiviral drug development.
- To highlight the contributions of our group in developing carbohydrate multivalent systems targeting DC-SIGN.
Main Methods:
- Review of existing literature on DC-SIGN and carbohydrate-based antiviral strategies.
- Synthesis and characterization of various carbohydrate multivalent systems presented on different scaffolds.
Main Results:
- DC-SIGN's established role in innate immunity and pathogen recognition.
- Demonstration of carbohydrate multivalent systems as effective tools for targeting DC-SIGN.
- Significant advancements in the design and application of these systems by our research group.
Conclusions:
- Carbohydrate multivalent systems targeting DC-SIGN show great promise for antiviral drug development.
- Further research in this area can lead to novel therapeutic strategies against infectious diseases.
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