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Updated: Nov 6, 2025

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Platinum complexes act as shielding agents against virus infection
Benjamin Bailly1, Anil K Gorle1, Larissa Dirr1
1Institute for Glycomics, Griffith University Gold Coast Campus, Southport, Queensland, Australia. m.vonitzstein@griffith.edu.au.
Abstract:
We determine that the substitution-inert polynuclear platinum complex (PPC) TriplatinNC is an antiviral agent and protects cells from enterovirus 71 and human metapneumovirus infection. This protection occurs through the formation of adducts with cell-surface glycosaminoglycans. Our detailed mechanistic investigation demonstrates that TriplatinNC blocks viral entry by shielding cells from virus attack, opening new directions for metalloshielding antiviral drug development.
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