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Updated: Nov 6, 2025
07:15
An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
Published on: July 31, 2019
9.9K
Probiotics and gut health
Emidio Scarpellini1,2, Martina Basilico3, Emanuele Rinninella4,5
1Unit of Clinical Nutrition and Internal Medicine, Madonna del Soccorso General Hospital, San Benedetto del Tronto, Ascoli Piceno, Italy - scarpidio@gmail.com.
Minerva Gastroenterology
|May 12, 2021
Summary
Gut microbial dysbiosis is linked to numerous gastrointestinal diseases. Modulating this gut ecosystem with probiotics shows promise for treatment.
Area of Science:
- Gastroenterology
- Microbiology
- Human Health
Background:
- The gut microbiota is a complex intestinal ecosystem crucial for maintaining human health.
- Microbial imbalances, or dysbiosis, are implicated in various gastrointestinal disorders.
- Understanding the gut microbiota's role is vital for disease management.
Purpose of the Study:
- To review the association between gut microbial dysbiosis and gastrointestinal diseases.
- To explore the potential of probiotic interventions in managing these conditions.
Main Methods:
- A narrative review was conducted.
- Searches were performed on PubMed, Medline, and Embase databases.
- Inclusion criteria comprised English language papers, reviews, meta-analyses, case series, and randomized controlled trials (RCTs).
Main Results:
- Gut microbiota alterations are associated with diverse gastrointestinal diseases, including IBS, NAFLD, cancers, celiac disease, IBD, and CDI.
- Microbial dysbiosis impacts the pathophysiology of these conditions.
- Probiotic interventions for dysbiosis are safe and feasible in select cases.
Conclusions:
- Gut microbial dysbiosis is significantly associated with the pathophysiology of various gastrointestinal diseases.
- Remodeling gut microbiota with probiotics demonstrates promising efficacy in certain gastrointestinal conditions.
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