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Updated: Nov 6, 2025

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Published on: February 16, 2020
Manganese-Mediated Direct Functionalization of Hantzsch Esters with Alkyl Iodides via an
Xian-Guan Liu1, Ci-Shuang Dong1, Fei Li1
1State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Abstract:
We report, for the first time, manganese-mediated direct functionalization of the Hantzsch esters with readily accessible alkyl iodides through an aromatization-dearomatization strategy. Applying this protocol, a library of valuable 4-alkyl-1,4-dihydropyridines were facilely afforded in good yields. This simple and practical reaction proceeds under visible-light irradiation at room temperature and displays high functional-group compatibility. Additionally, the method is applicable for gram-scale synthesis and late-stage functionalization of complex molecules.
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