Related Experiment Video
Updated: Nov 6, 2025
Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
Published on: January 12, 2022
Two Cases of Extremely High-IL-6 Pan-uveitis with Subretinal Exudation and Cell Migration
Mizuki Tagami1, Norihiko Misawa1, Atsushi Sakai1
1Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Osaka City University, Osaka, Japan.
Purpose:
To describe two cases of extremely high-IL-6 pan-uveitis with subretinal exudation and cell migration.
Methods:
Pre-operative and postoperative images and IL-6 values in vitreous samples of two pan-uveitis cases were analyzed.
Results:
Case 1 was a 76-year-old man with blurry vision in his right eye. Fundus examination and optical coherence tomography showed vitreous opacification with vitreous cells and the presence of a white-yellowish retinal exudate with peripheral choroidal detachment all around. The IL-6 value was 16,600 pg/ml. Case 2 was a 63-year-old man with blurry vision in his right eye. On fundus examination, there was severe vitreous opacification in his right eye. The IL-6 value was 26,600 pg/ml. Importantly, there was good responsiveness to steroids and the TNF inhibitor.
Conclusion:
Unclassified intraocular inflammation might include a new category of disease with unilateral pan-uveitis with good response to steroid therapy and extremely high vitreous IL-6 values.
