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Updated: Nov 6, 2025

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Ultrasonic-augmented Primary Adult Fibroblast Isolation
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Fibroblast tissue priming-not so nice to C you!
Behdad Afzali1, Claudia Kemper2
1Immunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Immunity
|May 12, 2021
Abstract:
The molecular mechanisms explaining why relapses of inflammatory arthritis occur at previously affected sites are unknown. In this issue of Immunity, Friščić et al. propose that local fibroblasts perpetuate inflammation after priming through cell-intrinsic complement C3, which reprograms their bioenergetics and activates the inflammasome.

