Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Role of Hippocampus in Memory

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A wireless subdural-contained brain-computer interface with 65,536 electrodes and 1,024 channels.

Nature electronics·2026

Same author

Hereditary angioedema attack trends among patients maintained on lanadelumab long-term prophylaxis.

The journal of allergy and clinical immunology. Global·2026

Same author

Lonvoguran Ziclumeran - In Vivo CRISPR Gene Editing in Hereditary Angioedema.

The New England journal of medicine·2026

Same author

Investigating the Dynamic Relationship Between Anxiety and Spatial Memory Using Autonomous Ecological Momentary Assessment.

Research square·2026

Same author

Hidden Spirals Reveal the Neurocomputational Mechanisms of Traveling Waves in Human Memory.

bioRxiv : the preprint server for biology·2026

Same author

Evaluating place cell detection methods in Rats and Humans: Implications for cross-species spatial coding.

PLoS computational biology·2026

Search research articles

Related Experiment Video

Updated: Nov 6, 2025

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit

Published on: August 2, 2017

Phase precession in the human hippocampus and entorhinal cortex.

Salman E Qasim¹, Itzhak Fried², Joshua Jacobs¹

¹Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.

|May 12, 2021

Summary

Theta phase precession, a neural mechanism for sequential event representation, is demonstrated in humans for the first time. This finding extends its known role in spatial navigation and memory to humans, including non-spatial goal states.

Keywords:

entorhinal cortex frontal cortex goal-directed navigation hippocampus phase precession place cells temporal coding theta oscillations

More Related Videos

Acute Mouse Brain Slicing to Investigate Spontaneous Hippocampal Network Activity

Acute Mouse Brain Slicing to Investigate Spontaneous Hippocampal Network Activity

Published on: August 28, 2020

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

Related Experiment Videos

Last Updated: Nov 6, 2025

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit

Published on: August 2, 2017

Acute Mouse Brain Slicing to Investigate Spontaneous Hippocampal Network Activity

Acute Mouse Brain Slicing to Investigate Spontaneous Hippocampal Network Activity

Published on: August 28, 2020

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

Area of Science:

Neuroscience
Cognitive Science
Neurophysiology

Background:

Spatial navigation and memory rely on understanding one's position and trajectory.
Theta phase precession, observed in rodents, is a hypothesized mechanism where neurons activate at earlier theta oscillation phases to represent sequential locations.
This neural pattern is thought to be crucial for learning and memory.

Purpose of the Study:

To investigate whether theta phase precession occurs in humans during spatial navigation.
To determine if this neural mechanism extends beyond spatial representations to include non-spatial information, such as goal states.

Main Methods:

Recorded single-neuron activity in the human hippocampus and entorhinal cortex during spatial navigation tasks.
Analyzed neuronal firing patterns in relation to the local network theta oscillations.

Main Results:

Spatially tuned neurons in the human hippocampus and entorhinal cortex exhibited theta phase precession.
Evidence was found for phase precession related to specific goal states, not just locations.

Conclusions:

Theta phase precession is present in humans, confirming its role in spatial representation.
This phenomenon has a broader functional role in the brain, encompassing both spatial and non-spatial information processing for memory and navigation.