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Development of a highly sensitive sensor chip using optical diagnostic based on functionalized plasmonically active

Vu Thi Huong1, Hanh Kieu Thi Ta2,3,4, Ngoc Xuan Dat Mai3,4

  • 1Faculty Department of Information Communication, Convergence Technology, Soongsil University, Seoul 06978, Republic of Korea.

Nanotechnology
|May 12, 2021
PubMed
Summary
This summary is machine-generated.

This study introduces a novel localized surface plasmon resonance (LSPR) biosensor using multimode fiber for sensitive detection of bovine serum albumin (BSA) protein concentration. The advanced fiber optic biosensor achieves a low detection limit, offering a promising alternative to conventional fluorescence methods.

Keywords:
biosensorsbovine serum albumingold nanoparticleslocalized surface plasmon resonanceoptical fiber

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Area of Science:

  • Optoelectronics
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Accurate solution concentration measurement is crucial across various scientific disciplines, including chemical analysis, clinical diagnostics, and environmental monitoring.
  • Existing biosensing techniques often face limitations in sensitivity, efficiency, or complexity.
  • Label-free optical biosensors offer advantages by eliminating the need for secondary labeling agents.

Purpose of the Study:

  • To develop a highly sensitive and efficient transmission-mode localized surface plasmon resonance (LSPR) sensor system for measuring solution concentrations.
  • To utilize multimode fiber technology for a convenient and robust biosensing platform.
  • To demonstrate the sensor's capability in detecting bovine serum albumin (BSA) protein concentration.

Main Methods:

  • Fabrication of a sensor chip by decorating gold nanoparticles (AuNPs) onto a clad-free multimode fiber using a self-assembly process.
  • Functionalization of the sensor head with carboxyl bonds for target molecule immobilization.
  • Detection principle based on the refractive index difference and numerical aperture variation caused by analyte concentration changes.
  • Measurement of output signal power changes at a He-Ne wavelength of 632.8 nm.

Main Results:

  • The LSPR sensor demonstrated high sensitivity and efficiency in detecting bovine serum albumin (BSA) protein.
  • A low detection limit of 0.075 ng/mL for BSA protein was achieved.
  • The sensor system effectively converted refractive index variations into measurable output signal power changes.

Conclusions:

  • The developed multimode fiber LSPR biosensor offers a highly sensitive and label-free method for concentration measurement.
  • The sensor's performance indicates significant potential for improving sensitivity in label-free biosensing.
  • This technology presents a viable alternative to conventional fluorescence-based biosensing techniques.