Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

218
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
218
Ratio Level of Measurement00:54

Ratio Level of Measurement

19.8K
The way a set of data is measured is called its level of measurement. Correct statistical procedures depend on a researcher being familiar with levels of measurement. For analysis, data are classified into four levels of measurement—nominal, ordinal, interval, and ratio.
A set of data measured using the ratio scale takes care of the ratio problem and provides complete information. Ratio scale data are like interval scale data, except they have a zero point and ratios can be calculated....
19.8K
Bioequivalence Data: Statistical Interpretation01:16

Bioequivalence Data: Statistical Interpretation

40
Body:The statistical interpretation of bioequivalence data is a significant aspect of pharmaceutical research. Bioequivalence refers to the absence of any significant difference in the rate and extent to which the active ingredient in pharmaceutical products becomes available at the site of drug action when administered at the same molar dose under similar conditions. This helps determine if different drug products have similar absorption rates, ensuring their interchangeability.Statistical...
40
Nursing Interventions II: Selecting and Classifying the Nursing Interventions01:29

Nursing Interventions II: Selecting and Classifying the Nursing Interventions

2.7K
Creating and executing a nursing diagnosis helps nurses plan care and guide patient, family, and community interventions. They are developed based on a patient's physical evaluation and support measuring the outcomes. It is not recommended to select random interventions throughout the planning process. Instead, consider the following six essential factors when choosing interventions:
2.7K
Regression Toward the Mean01:52

Regression Toward the Mean

6.6K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.6K
Actuarial Approach01:20

Actuarial Approach

174
The actuarial approach, a statistical method originally developed for life insurance risk assessment, is widely used to calculate survival rates in clinical and population studies. This method accounts for participants lost to follow-up or those who die from causes unrelated to the study, ensuring a more accurate representation of survival probabilities.
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
174

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sustainability of Biosimilars in Europe: A Delphi Panel Consensus with Systematic Literature Review.

Pharmaceuticals (Basel, Switzerland)·2020
Same author

Relative value assessment: characterizing the benefit of oncology therapies through diverse survival metrics from a US perspective.

ClinicoEconomics and outcomes research : CEOR·2019
Same author

How Data Packages Lacking Phase III Pivotal Trial Data Can Support Regulatory Approval and Reimbursement for Oncologics in Australia.

Value in health regional issues·2018
Same author

The Role of Noncomparative Evidence in Health Technology Assessment Decisions.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research·2017
Same author

Registration and Reimbursement of New Cancer Medicines in Australia-Response to Letter to the Editor by Michael Wonder.

Value in health regional issues·2016
Same author

Blockade of PD-1 or p38 MAP kinase signaling enhances senescent human CD8(+) T-cell proliferation by distinct pathways.

European journal of immunology·2015

Related Experiment Video

Updated: Nov 5, 2025

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
06:16

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease

Published on: August 9, 2024

622

Accounting for inflation within NICE cost-effectiveness thresholds.

Vincent Low1, Richard Macaulay2

  • 1ACS Medical Ltd, Oxfordshire UK.

Expert Review of Pharmacoeconomics & Outcomes Research
|May 13, 2021
PubMed
Summary

National Institute for Health and Care Excellence (NICE) cost-effectiveness thresholds have lost value due to inflation since 2004. Adjusting for inflation would increase the number of Single Technology Appraisals (STAs) meeting NICE guidance.

Keywords:
ICERInflationNICEadjustmentthreshold

More Related Videos

Measuring Delay Discounting in Humans Using an Adjusting Amount Task
07:47

Measuring Delay Discounting in Humans Using an Adjusting Amount Task

Published on: January 9, 2016

15.7K
Minimally Invasive Thumb-sized Pterional Craniotomy for Surgical Clip Ligation of Unruptured Anterior Circulation Aneurysms
11:58

Minimally Invasive Thumb-sized Pterional Craniotomy for Surgical Clip Ligation of Unruptured Anterior Circulation Aneurysms

Published on: August 11, 2015

15.7K

Related Experiment Videos

Last Updated: Nov 5, 2025

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
06:16

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease

Published on: August 9, 2024

622
Measuring Delay Discounting in Humans Using an Adjusting Amount Task
07:47

Measuring Delay Discounting in Humans Using an Adjusting Amount Task

Published on: January 9, 2016

15.7K
Minimally Invasive Thumb-sized Pterional Craniotomy for Surgical Clip Ligation of Unruptured Anterior Circulation Aneurysms
11:58

Minimally Invasive Thumb-sized Pterional Craniotomy for Surgical Clip Ligation of Unruptured Anterior Circulation Aneurysms

Published on: August 11, 2015

15.7K

Area of Science:

  • Health economics
  • Pharmacoeconomics
  • Health technology assessment

Background:

  • The National Institute for Health and Care Excellence (NICE) uses a static Incremental Cost-Effectiveness Ratio (ICER) threshold range for drug reimbursement recommendations, unchanged since 2004.
  • Inflation has eroded the real value of these thresholds over time, potentially impacting appraisal outcomes.

Purpose of the Study:

  • To model the impact of inflation on NICE's cost-effectiveness thresholds.
  • To assess how inflation-adjusted thresholds would affect the appraisal outcomes of Single Technology Appraisals (STAs).

Main Methods:

  • Identification of all STAs recommended in 2019.
  • Evaluation of the most plausible Incremental Cost-Effectiveness Ratios (ICERs) against inflation-adjusted NICE thresholds.
  • Modeling the change in purchasing power of the pound from 2004 to 2019.

Main Results:

  • 41 STAs were analyzed, with 46% having base-case ICERs below £20,000/QALY.
  • Inflation caused a 43% decrease in the pound's purchasing power between 2004 and 2019.
  • Adjusting for inflation would necessitate NICE's ICER threshold to increase to £28,584-£42,876/QALY.
  • Using inflation-adjusted thresholds resulted in an 18% and 12% absolute increase in STAs falling below the lower and upper bounds, respectively.

Conclusions:

  • NICE's ICER thresholds have declined in real terms due to a lack of adjustment for inflation.
  • Further research is needed to determine if ICER thresholds should be dynamic and adjusted for factors like inflation.