Sub-ambient measurement of platelet function: the requirements for modification of a standard platelet aggregometer

This methodological report documents the electro-mechanical modifications that were applied to a commercially available aggregometer, in order to achieve direct platelet aggregation measurement at sub-ambient temperatures. This development provides a facility, not previously available, for examining certain aspects of platelet physiology at any desired temperature. This innovation was primarily developed for investigating optimum storage parameters for platelets, as they apply to clinical blood transfusion practice. However, a wider scope of application is envisaged, including its use as both a general research tool, and eventually as an additional component of clinical measurement in the routine coagulation laboratory. Some illustrative data is briefly provided.