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Polyelectrolyte Multi-Layered Griseofulvin Nanoparticles: Conventional versus Continuous In-Situ Layer-by-Layer
Sumayah Abdul-Jabbar, Gary P Martin1, Luigi G Martini1
1School of Cancer and Pharmaceutical Science, Institute of Pharmaceutical Science, King's College London, Franklin-Wilkins Building, 150 Stamford street, London SE1 9NH, United Kingdom.
Journal of Nanoscience and Nanotechnology
|May 13, 2021
Summary
Polyelectrolyte multilayers enhance griseofulvin nanoparticle stability for drug delivery. The conventional method produced smaller, more stable nanoparticles compared to the continuous in situ approach.
Area of Science:
- Materials Science
- Nanotechnology
- Pharmaceutical Sciences
Background:
- Polyelectrolyte multilayers (PEM) offer enhanced stability for colloidal systems.
- PEM are promising for drug delivery, especially for poorly soluble drugs.
- Griseofulvin (GF) is a poorly water-soluble drug with potential for improved delivery.
Purpose of the Study:
- To fabricate PEM on griseofulvin nanoparticles (GF NPs).
- To compare two methods for PEM fabrication: conventional and continuous in situ.
- To evaluate the impact of PEM on GF NP size and stability.
Main Methods:
- Griseofulvin nanoparticles (300 nm) were prepared using wet bead milling with poly(sodium 4-styrenesulfonate) (PSS).
- PEM were constructed using alternating layers of chitosan and PSS via conventional (excess polymer, centrifugation) and continuous in situ (high shear mixing) methods.
- Nanoparticle size and stability were assessed over six months.
Main Results:
- Both conventional and continuous in situ methods successfully generated PEM on GF NPs.
- The conventional method resulted in smaller GF NPs (282 ±9 nm) compared to the continuous in situ method (497 ±34 nm).
- GF NPs fabricated by the conventional method exhibited significantly higher physical stability over six months.
Conclusions:
- Griseofulvin nanosuspensions are suitable for PEM fabrication.
- The conventional PEM fabrication method yields more stable nanoparticles.
- PEM coating offers a pathway for developing enhanced griseofulvin drug delivery systems.
