Outcome after surgical resection of multiple recurrent retroperitoneal soft tissue sarcoma

Area of Science:

• Oncology
• Surgical Oncology
• Sarcoma Research

Background:

• Local recurrences (LR) and distant metastases (DM) are frequent in retroperitoneal soft tissue sarcoma (RPS).
• While prognostic factors for first tumor relapse are known, those for subsequent recurrences remain poorly defined.
• Identifying these factors is crucial for improving patient outcomes.

Purpose of the Study:

• To identify prognostic factors for overall survival (OS) in patients with multiple recurrences of RPS.
• To evaluate the impact of tumor resection on survival after first, second, and third recurrences.

Main Methods:

• Retrospective analysis of 201 patients with primary and recurrent RPS undergoing resection.
• Multivariable Cox regression analyses to identify predictors of OS, LR-free survival, and DM-free survival.
• Subgroup analyses for liposarcoma and leiomyosarcoma.

Main Results:

• Over 12 months to recurrence and complete resection were associated with improved OS after first and second LR.
• Incomplete resection of first, second, and third recurrences was an independent predictor of poor OS (p < 0.001).
• 5-year OS for first/second LR with resection was 64%/62% vs. 20%/46% without resection.

Conclusions:

• Patients with RPS benefit from tumor resection not only for the first recurrence but also for subsequent relapses.
• Complete resection of recurrent RPS is a significant positive prognostic factor for overall survival.