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Retinal Pathophysiological Evaluation in a Rat Model
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Structural evaluation in inherited retinal diseases.

Malena Daich Varela1,2, Burak Esener3, Shaima A Hashem1,2

  • 1Moorfields Eye Hospital City Road Campus, London, UK.

The British Journal of Ophthalmology
|May 13, 2021
PubMed
Summary
This summary is machine-generated.

Advancements in ophthalmic genetics and translational medicine enable precise assessment of inherited retinal diseases (IRD). This review details imaging techniques for evaluating retinal structure in IRD patients undergoing therapeutic trials.

Keywords:
clinical trialdystrophygeneticsimagingretina

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Area of Science:

  • Ophthalmic genetics
  • Translational medicine
  • Retinal imaging technologies

Background:

  • Ophthalmic genetics has seen rapid evolution, driven by progress in translational medicine for inherited retinal diseases (IRD).
  • Accurate assessment of retinal structure is crucial for understanding IRD progression and evaluating therapeutic interventions.

Purpose of the Study:

  • To review objective and accurate methods for assessing retinal structure in patients with IRD.
  • To highlight the utility of various imaging techniques in the context of ongoing therapeutic efforts for IRD.

Main Methods:

  • Review of standard-of-care imaging: color fundus photography, fundus autofluorescence, and optical coherence tomography (OCT).
  • Inclusion of advanced imaging technologies: OCT angiography, adaptive optics imaging, multi-wavelength fundus imaging, MRI, laser speckle flowgraphy, and retinal oximetry.
  • Illustration of imaging utility with paradigm genotypes relevant to ongoing therapeutic trials.

Main Results:

  • Standard and advanced imaging techniques provide objective and accurate assessments of retinal structure in IRD.
  • Each technology offers unique insights into retinal morphology and function relevant to specific genetic profiles.
  • Imaging data is vital for monitoring disease progression and assessing treatment efficacy in clinical trials.

Conclusions:

  • A comprehensive array of imaging modalities is available for evaluating retinal structure in IRD.
  • These techniques are essential tools in the rapidly advancing field of ophthalmic genetics and IRD therapeutics.
  • Objective structural assessment via imaging supports the development and evaluation of novel treatments for inherited retinal diseases.