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Association between serum level of C-reactive protein and risk of cardiovascular events based on cohort studies

Xingjin Yang1, Dongdong Zhang2, Yang Zhao1

  • 1Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China.

Journal of Human Hypertension
|May 13, 2021
PubMed

Insights

Higher C-reactive protein (CRP) levels significantly increase the risk of cardiovascular events (CVEs), including cardiovascular disease, stroke, and coronary heart disease. This quantitative analysis confirms a dose-response relationship between CRP and CVE risk.

Area of Science:

  • Cardiology
  • Biomarkers
  • Epidemiology

Background:

  • Serum C-reactive protein (CRP) is a known inflammation marker.
  • Previous studies suggest an association between CRP levels and cardiovascular events (CVEs).
  • A comprehensive quantitative assessment of this association was lacking.

Purpose of the Study:

  • To quantitatively evaluate the association between serum CRP levels and the risk of CVEs.
  • To assess the dose-response relationship between CRP and cardiovascular disease (CVD), stroke, and coronary heart disease (CHD).

Main Methods:

  • Meta-analysis of 36 articles (60 studies; 227,715 participants) from PubMed and Embase up to December 6, 2019.
  • Generalized least-squares regression models and restricted cubic splines were used.
  • Studies were treated independently to include diverse populations and CVE types.

Main Results:

  • High versus low CRP levels showed pooled relative risks (RRs) of 1.64 for CVD, 1.46 for stroke, and 1.55 for CHD.
  • A linear association was observed between CRP levels and CVEs.
  • Each 1-mg/L increase in CRP was associated with RRs of 1.18 for CVD, 1.07 for stroke, and 1.12 for CHD.

Conclusions:

  • Serum CRP level is a significant predictor of cardiovascular event risk.
  • Increasing CRP levels correlate with a progressively higher risk of CVD, stroke, and CHD.
  • This meta-analysis provides quantitative evidence supporting CRP as a risk factor for cardiovascular events.

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