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Dupilumab Induced Limbal Stem Cell Deficiency
Urmi Mehta1,2, Marjan Farid1
1Gavin Herbert Eye Institute, Department of Ophthalmology, University of California, Irvine, CA, 92697, USA.
International Medical Case Reports Journal
|May 13, 2021
Summary
Dupilumab, used for atopic dermatitis, may cause severe eye issues like limbal stem cell deficiency (LSCD) with long-term use. This case highlights LSCD as a serious ocular complication from Dupilumab treatment.
Area of Science:
- Ophthalmology
- Dermatology
- Immunology
Background:
- Dupilumab is an effective monoclonal antibody for treating atopic dermatitis (AD).
- Ocular side effects, including conjunctivitis and dry eye, are increasingly reported with Dupilumab use.
- The long-term ocular safety profile requires ongoing investigation.
Observation:
- A case report details a 56-year-old male with atopic dermatitis treated with Dupilumab.
- The patient presented with progressive vision clouding and symblepharon.
- Slit lamp examination revealed cicatrizing blepharoconjunctivitis and secondary limbal stem cell deficiency (LSCD).
Findings:
- Prolonged Dupilumab therapy was associated with the development of severe ocular complications.
- The patient was diagnosed with secondary LSCD attributed to cicatrizing blepharoconjunctivitis.
- This suggests a potential link between long-term Dupilumab use and LSCD.
Implications:
- Limbal stem cell deficiency (LSCD) represents a significant adverse ocular event associated with Dupilumab.
- Clinicians should be vigilant for ocular complications in patients on long-term Dupilumab treatment.
- Further research is needed to understand the mechanisms and incidence of LSCD in Dupilumab users.
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