Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Transcytosis of IgG01:15

Transcytosis of IgG

3.5K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
3.5K
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

792
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
792
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

598
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
598
Development of Immunocompetence01:22

Development of Immunocompetence

554
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
554
Antibody Structure01:10

Antibody Structure

62.2K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
62.2K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

475
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
475

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Astragalus polysaccharides reshape gut resistome of postpartum dairy cows.

Bioresource technology·2026
Same author

Toxicological and Liver Antioxidant Evaluation of Phillygenin Following Acute and Sub-Chronic Oral Administration.

Journal of applied toxicology : JAT·2026
Same author

Effects of Chinese herbal mixture extract on growth, immunity, antioxidant status, and modulates rumen microbiota in weaned lambs.

Veterinary journal (London, England : 1997)·2026
Same author

CRM1-dependent nuclear export of TRIM28 promotes MAVS K48-linked ubiquitination and suppresses RIG-I-mediated antiviral response.

Frontiers in immunology·2026
Same author

Dietary Bazhen San solid-state fermentation product improves laying performance, immunity and intestinal health in laying hens during the late laying period.

Frontiers in immunology·2026
Same author

Machine vision-based angle-arrayed imaging and two-stage deep learning for gear defect detection.

Applied optics·2026

Related Experiment Video

Updated: Nov 5, 2025

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

24.7K

Innate Mechanisms in Selective IgA Deficiency.

Jingyan Zhang1,2, Dèlenn van Oostrom1, JianXi Li2

  • 1Cell Biology and Immunology Group, Wageningen University & Research, Wageningen, Netherlands.

Frontiers in Immunology
|May 13, 2021
PubMed
Summary

Selective IgA deficiency (SIgAD) is a common immunodeficiency. This review explores its causes, focusing on innate immunity, genetics like TNFRSF13B, epigenetics, and environmental factors, to understand symptom variability.

Keywords:
T-cell independent switchingTACITNFRSF13B geneTregepigenetic imprintinginnate mechanismsselective IgA deficiency

More Related Videos

Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy
14:18

Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy

Published on: October 13, 2023

2.0K
Murine Nasal Lavage Fluid Collection without Blood Contamination
05:12

Murine Nasal Lavage Fluid Collection without Blood Contamination

Published on: July 11, 2025

1.1K

Related Experiment Videos

Last Updated: Nov 5, 2025

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

24.7K
Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy
14:18

Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy

Published on: October 13, 2023

2.0K
Murine Nasal Lavage Fluid Collection without Blood Contamination
05:12

Murine Nasal Lavage Fluid Collection without Blood Contamination

Published on: July 11, 2025

1.1K

Area of Science:

  • Immunology
  • Genetics
  • Microbiology

Background:

  • Selective IgA deficiency (SIgAD) is the most common primary immunodeficiency, often presenting after age four.
  • While many individuals with SIgAD are asymptomatic, some experience infections, allergies, and autoimmune diseases, with unclear reasons for this heterogeneity.
  • Recent findings suggest clinical manifestations can appear in newborns and infants due to immune defense abnormalities.

Purpose of the Study:

  • To review the characteristics of the innate immune system influencing T-cell independent IgA production.
  • To elucidate mechanisms underlying the development of SIgAD.
  • To explore the role of genetics (e.g., TNFRSF13B), epigenetics (e.g., TNFRSF13B methylation), and environmental factors (e.g., gut microbiota) in SIgAD.

Main Methods:

  • Literature review focusing on innate immunity, T-cell independent IgA production, and SIgAD.
  • Analysis of genetic factors, including the TNFRSF13B gene (TACI).
  • Examination of epigenetic modifications and environmental influences like gut microbiota.

Main Results:

  • The innate immune system plays a crucial role in T-cell independent IgA production, impacting SIgAD development.
  • Genetic factors, such as variations in TNFRSF13B, are associated with SIgAD.
  • Epigenetic factors (TNFRSF13B methylation) and environmental factors (gut microbiota) are implicated in the pathogenesis and heterogeneous clinical presentation of SIgAD.

Conclusions:

  • Understanding the interplay of innate immunity, genetics, epigenetics, and environment is key to explaining SIgAD heterogeneity.
  • Further research into these factors could lead to novel therapeutic strategies for SIgAD, as no specific treatment currently exists.