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Updated: Nov 5, 2025

Refined Murine Model of Idiopathic Pulmonary Fibrosis
Published on: June 17, 2025
HRCT Diagnosis of Pleuroparenchymal fibroelastosis: Report of two cases
Ali Morshid1, Amin Moshksar1, Aparna Das2
1Department of Diagnostic Radiology, University of Texas Medical Branch, Galveston TX 77555.
Abstract:
Pleuroparenchymal fibroelastosis (PPFE) is a rare idiopathic interstitial pneumonia that is often underdiagnosed on computed tomography scans. The disease process involves a combination of fibrosis involving the visceral pleura and fibroelastic changes within the subpleural lung parenchyma. Although definitive diagnosis is based on pathological evaluation, this is often not feasible and pattern recognition on CT as "definite PPFE" or "consistent with PPFE" is important given that sub group of patients will undergo rapid progression with clinical deterioration.
Insights
Pleuroparenchymal fibroelastosis (PPFE) is a rare lung disease often missed on CT scans. Recognizing CT patterns is crucial for identifying patients who may experience rapid disease progression and clinical decline.
Area of Science:
- Pulmonology
- Radiology
- Pathology
Background:
- Pleuroparenchymal fibroelastosis (PPFE) is a rare idiopathic interstitial pneumonia.
- It is characterized by fibrosis of the visceral pleura and subpleural lung parenchyma.
- PPFE is frequently underdiagnosed on computed tomography (CT) scans.
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