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Related Experiment Video

Updated: Nov 5, 2025

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

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Delayed Calcium Normalization after Successful Parathyroidectomy in Primary Hyperparathyroidism.

Iván Emilio de la Cruz Rodríguez¹, Elsy Sarahí García Montesinos¹, María Fernanda Rodríguez-Delgado²

¹Endocrinology Department. Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Mexico City 067200, Mexico.

Case Reports in Endocrinology

|May 13, 2021

Summary

Successful parathyroidectomy for primary hyperparathyroidism (PHPT) can still lead to delayed calcium normalization in about 10% of patients. Monitoring calcium levels post-surgery is crucial for assessing outcomes.

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Area of Science:

Endocrinology
Surgical Oncology

Background:

Primary hyperparathyroidism (PHPT) is effectively treated by parathyroidectomy.
A >50% decrease in parathormone (PTH) and normalized serum calcium within 72 hours post-surgery indicate successful treatment.

Observation:

This case report details a 38-year-old PHPT patient with delayed calcium normalization post-parathyroidectomy.
Hypercalcemia persisted for 120 hours despite a >50% PTH decrease within 24 hours, confirming surgical success.

Findings:

Approximately 10% of patients experience transient, persistent postoperative hypercalcemia after curative parathyroidectomy.
Higher preoperative serum calcium and PTH levels are associated with a greater likelihood of this delayed normalization.

Implications:

Persistent hypercalcemia beyond one month suggests residual PHPT, necessitating careful monitoring.
Postoperative calcium monitoring is vital for predicting short- and long-term patient prognosis after parathyroidectomy.