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Updated: Nov 5, 2025

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
Isocyanide-Based Multicomponent Reactions of Free Phenylboronic Acids
Constantinos G Neochoritis1,2, Tryfon Zarganes-Tzitzikas1, Michaela Novotná1
1Department of Pharmacy, Drug Design Group, University of Groningen, A. Deusinglaan 1, 9713 AV, The Netherlands.
Abstract:
Boronic acids are amongst the most useful synthetic intermediates, frequently used by modern drug design. However, their access and fast synthesis of libraries are often problematic. We present a methodology on the synthesis of drug-like scaffolds via IMCRs with unprotected phenylboronic acids. To demonstrate an application of our approach, we also performed one-pot Suzuki couplings on the primary MCR scaffolds. Moreover, we performed a thorough data-mining of the Cambridge Structural Database, revealing interesting geometrical features.
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