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Related Concept Videos

Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

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Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
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Bioavailability Enhancement: Drug Solubility Enhancement01:16

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Body:Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
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Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

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Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Updated: Nov 5, 2025

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform
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Lipid Nanoparticles as Carriers for Bioactive Delivery.

Neerupma Dhiman1, Rajendra Awasthi1, Bhupesh Sharma1

  • 1Amity Institute of Pharmacy, Amity University Uttar Pradesh, Noida, India.

Frontiers in Chemistry
|May 13, 2021
PubMed
Summary

Nanotechnology enhances drug delivery for poorly soluble lipophilic drugs, improving bioavailability. Lipid nanoparticles offer a promising approach, with ongoing research in solid lipid nanoparticles (SLNs) and nanostructure lipid carriers (NLCs).

Keywords:
nanostructure lipid carriersrecent advancesscale upsolid lipid nanoparticlesstabilitytoxicity

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Area of Science:

  • Pharmaceutical Nanotechnology
  • Drug Delivery Systems
  • Lipid Nanoparticles

Background:

  • Over 40% of approved drugs are lipophilic with poor solubility, limiting their bioavailability.
  • Poor drug solubility is a major challenge in pharmaceutical development and formulation.
  • Nanotechnology offers solutions for targeted delivery and improved solubility of lipophilic drugs.

Purpose of the Study:

  • To provide a comprehensive review of lipid nanoparticles as carriers for bioactive molecules.
  • To discuss the synthesis, characterization, advantages, disadvantages, toxicity, and medical applications of lipid nanoparticles.
  • To update on recent developments, patents, and clinical trials involving solid lipid nanoparticles (SLNs) and nanostructure lipid carriers (NLCs).

Main Methods:

  • Literature review of nanotechnology applications in drug delivery.
  • Analysis of various nanotechnology-based drug delivery systems, including lipid nanoparticles.
  • Examination of recent advancements in SLNs and NLCs, including patents and clinical trials.

Main Results:

  • Nanotechnology, particularly lipid nanoparticles, significantly improves solubility and bioavailability of lipophilic drugs.
  • Solid lipid nanoparticles (SLNs) and nanostructure lipid carriers (NLCs) are advanced systems with diverse applications.
  • Recent developments show increasing patent activity and clinical trials for SLNs and NLCs.

Conclusions:

  • Lipid nanoparticles represent a key innovation in overcoming drug delivery limitations.
  • Further research and clinical translation of SLNs and NLCs hold significant promise for pharmaceutical and medical fields.
  • Nanotechnology-based drug delivery systems are crucial for enhancing therapeutic efficacy.