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Updated: Nov 5, 2025

Identification of Circular RNAs using RNA Sequencing
Published on: November 14, 2019
Emerging Roles of Circular RNAs in Thyroid Cancer
Fada Xia1, Zeyu Zhang1, Xinying Li1
1Department of Thyroid Surgery, Xiangya Hospital, Central South University, Changsha, China.
Abstract:
Thyroid cancer (TC) has the highest incidence among endocrine malignancies. Thus, it is essential to achieve a deep understanding of various mechanisms of development and progression of TC. circRNAs are recognized by multiple studies as being dysregulated in TC. Accumulating evidences have revealed that circRNAs serve as regulatory molecules involved in various biological processes in TC, including cell proliferation, apoptosis, invasion/migration, metabolism, and chemoresistance. Furthermore, circRNA can also serve as an effective tool in TC researches of diagnosis, prognosis, and treatments. Thus, this review is to outline the characteristics of circRNAs, generalize their categories and functions, and highlight the expression of circRNAs in TC. Meanwhile, we are expecting to achieve a comprehensive understanding of new therapies based on circRNAs in treating or preventing TC.
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