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Updated: Nov 5, 2025

Preparation of Oligomeric β-amyloid1-42 and Induction of Synaptic Plasticity Impairment on Hippocampal Slices
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Amyloid-β Oligomers Induce Only Mild Changes to Inhibitory Bouton Dynamics

Marvin Ruiter1, Christine Lützkendorf1, Jian Liang1

  • 1Department of Cell Biology, Neurobiology and Biophysics, Faculty of Science, Utrecht University, Utrecht, The Netherlands.

Journal of Alzheimer'S Disease Reports
|May 13, 2021
PubMed
Summary

Inhibitory neurons do not significantly contribute to Alzheimer's disease hyperexcitability. Short-term amyloid-β exposure had minimal effects on inhibitory bouton dynamics in mouse models.

Keywords:
Amyloidosis modelshyperexcitabilityinhibitory synapsespresynaptic boutonsstructural plasticitytwo-photon imaging

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