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Measurement of Tumor T2* Relaxation Times after Iron Oxide Nanoparticle Administration
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Reproducibility of liver R2* quantification for liver iron quantification from cardiac R2* acquisitions.

M R Muehler1,2, K Vigen3,4, D Hernando3,5,4,6

  • 1Department of Radiology, Wisconsin Institutes of Medical Research, University of Wisconsin, Room 2478, 1111 Highland Avenue, Madison, WI, 53705, USA. muhler@wisc.edu.

Abdominal Radiology (New York)
|May 13, 2021
PubMed
Summary
This summary is machine-generated.

Two-dimensional (2D) cardiac magnetic resonance imaging (MRI) R2* measurements are reproducible for liver iron quantification compared to 3D liver MRI. However, the 2D method may underestimate liver R2* values exceeding 400 s⁻¹.

Keywords:
2D cardic3D liverLiver ironR2* mapping

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Area of Science:

  • Radiology
  • Medical Imaging
  • Biophysics

Background:

  • Liver R2* measurements are crucial for quantifying iron overload.
  • Standardizing MRI techniques is essential for accurate liver iron quantification.
  • Comparing different MRI acquisition methods ensures reliable diagnostic outcomes.

Purpose of the Study:

  • To assess the reproducibility of liver R2* measurements between 2D cardiac ECG-gated and 3D breath-hold MRI sequences.
  • To evaluate the suitability of 2D cardiac MRI for liver iron quantification.

Main Methods:

  • A total of 54 1.5 T MRI exams were analyzed.
  • 2D cardiac and 3D liver R2* maps were acquired and reconstructed using a complex R2* algorithm.
  • Colocalized regions of interest (ROIs) in the liver were used for data analysis.

Main Results:

  • High correlation and concordance were observed between 2D and 3D R2* measurements.
  • Bland-Altman analysis showed good agreement, with a slight increase in mean R2* above 400 s⁻¹.
  • The 2D method is feasible but may underestimate R2* values exceeding 400 s⁻¹.

Conclusions:

  • 2D cardiac R2* mapping is a reproducible method for liver iron quantification compared to 3D liver R2* mapping.
  • The 2D cardiac R2* mapping method may underestimate liver R2* values when they exceed 400 s⁻¹.
  • Further validation is needed for high R2* values using the 2D cardiac method.