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Clinical Features and Management of Stenotrophomonas Maltophilia Keratitis

B-C Park1, Hwa-Rang Lim1, Seon-Joo Park2

  • 1Department of Ophthalmology, Chosun University College of Medicine, 365 Pilmun-daero, Dong-gu, Gwangju, Republic of Korea.

Ophthalmology and Therapy
|May 13, 2021
PubMed
Abstract

Insights

Stenotrophomonas maltophilia keratitis is an uncommon but serious eye infection. A combination of fluoroquinolone, beta-lactam, and aminoglycoside antibiotics is recommended for effective treatment.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Microbiology

Background:

  • Stenotrophomonas maltophilia keratitis is a rare corneal infection.
  • This study investigated its clinical features, antibiotic susceptibility, and outcomes.

Purpose of the Study:

  • To analyze risk factors, clinical presentation, and treatment outcomes for S. maltophilia keratitis.
  • To determine effective antibiotic strategies for S. maltophilia eye infections.

Main Methods:

  • Retrospective review of 16 patients with culture-proven S. maltophilia keratitis (2015-2020).
  • Analysis of clinical data including risk factors, presentation, antibiotic sensitivities, and visual acuity outcomes.

Main Results:

  • Common risk factors included trauma, contact lens use, and prior herpes simplex virus keratitis.
  • Most isolates were susceptible to fluoroquinolones (93.8%), aminoglycosides (87.5%), and beta-lactams (81.3%).
  • A combination antibiotic regimen of fluoroquinolone, beta-lactam, and aminoglycoside showed significantly better visual acuity outcomes (p=0.039).

Conclusions:

  • S. maltophilia keratitis is an opportunistic infection often linked to ocular surface instability.
  • A combination therapy including fluoroquinolone, beta-lactam, and aminoglycoside is the recommended treatment of choice.
Keywords:
Antibiotic susceptibilityKeratitisStenotrophomonas maltophilia

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