Heterogeneous associative plasticity in the auditory cortex induced by fear learning - novel insight into the
O Zelenka1, O Novak, A Brunova
1Department of Physiology, Second Faculty of Medicine, Charles University in Prague, Prague, Czech Republic. Ondrej.novak@lfmotol.cuni.cz.
Abstract:
We used two-photon calcium imaging with single-cell and cell-type resolution. Fear conditioning induced heterogeneous tuning shifts at single-cell level in the auditory cortex, with shifts both to CS+ frequency and to the control CS- stimulus frequency. We thus extend the view of simple expansion of CS+ tuned regions. Instead of conventional freezing reactions only, we observe selective orienting responses towards the conditioned stimuli. The orienting responses were often followed by escape behavior.
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