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Updated: Nov 5, 2025

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library
Published on: April 6, 2012
[Corrigendum] MicroRNA‑122 affects cell aggressiveness and apoptosis by targeting PKM2 in human hepatocellular
Qiuran Xu1, Meiqi Zhang1, Jianfeng Tu1
1Department of Emergency, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, P.R. China.
Abstract:
Following the publication of the above article, an interested reader drew to the authors' attention that Figs. 6C and 7A apparently contained overlapping panels, suggesting that these data for purportedly different experiments had been derived from the same original source. The wound‑healing result for the anti‑miR‑122+siRNA PKM2 experiment in the lower panel of Fig. 6C and the transwell invasion result for the anti‑miR‑122+siRNA PKM2 experiment in Fig. 7A were erroneously selected. Accordingly, the authors repeated these assays and were able to confirm that the results were in accordance with the published results. Consequently, the corrected versions of Figs. 6 and 7, containing the replacement data for Figs. 6C and 7A, are shown opposite. It should be emphasized that the inadvertent errors that occurred during the compilation of these figures did not affect the research results or the conclusions of this article. The authors all agree to this Corrigendum, and are grateful to the Editor of Oncology Reports for allowing them to have the opportunity to correct these errors. The authors also apologize to the readership for any inconvenience these errors may have caused. [the original article was published in Oncology Reports 34: 2054‑2064, 2015; DOI: 10.3892/or.2015.4175].
Insights
This corrigendum addresses errors in Figs. 6C and 7A of a previously published article. Corrected figures are provided, confirming that the original research findings and conclusions remain unaffected.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Context:
- The original article investigated the role of PKM2 in cancer, focusing on microRNA-122 (miR-122) and siRNA interventions.
- An overlap in figure panels was identified, raising concerns about data integrity for specific experiments.
Purpose:
- To correct inadvertent errors in the presentation of data in Figures 6C and 7A of a published study.
- To provide corrected figures and confirm the validity of the original research findings.
Summary:
- This corrigendum corrects data presentation errors in Figures 6C and 7A concerning anti-miR-122+siRNA PKM2 experiments.
- The assays were repeated, confirming the original results. Corrected figures are presented, ensuring data accuracy without altering conclusions.
Impact:
- Ensures the scientific record is accurate by correcting data visualization errors.
- Reaffirms the integrity of the original study's conclusions on PKM2, miR-122, and siRNA, despite minor presentation errors.
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