Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Oral Hypoglycemic Agents: Biguanides and Glitazones01:26

Oral Hypoglycemic Agents: Biguanides and Glitazones

389
Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
389
Oral Hypoglycemic Agents: Sulfonylureas01:17

Oral Hypoglycemic Agents: Sulfonylureas

468
Sulfonylureas are oral hypoglycemic agents utilized in treating type 2 diabetes. They are characterized by their unique sulfonylurea chemical structure. The family of sulfonylureas is divided into generations. First-generation sulfonylureas, including tolbutamide (Orinase), chlorpropamide (Diabinese), and tolazamide (Tolinase), trigger insulin release from pancreatic β cells and enhance peripheral tissues' insulin sensitivity. The second-generation members, such as glipizide...
468
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

3.4K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.4K
Antihypertensive Drugs: Action of Diuretics01:16

Antihypertensive Drugs: Action of Diuretics

1.9K
Diuretics are antihypertensive drugs used to treat hypertension resulting from sodium and water retention. Sodium, vital for fluid balance and nerve or muscle function, is regulated by the kidneys through millions of nephrons. Blood enters nephrons via afferent arterioles, which branch into capillaries called glomeruli. These filter blood plasma, allowing water and solutes, like sodium ions, to pass through capillary walls into Bowman's capsule. The filtrate then flows through various...
1.9K
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

276
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
276
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

166
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
166

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Global survey of genetic testing methods for familial hypercholesterolemia. A study and recommendations from the EAS FHSC registry.

European journal of preventive cardiology·2026
Same author

Importance and Management of Non-High-Density Lipoprotein Cholesterol in Dyslipidemia Treatment.

JACC. Asia·2026
Same author

Pharmacological management of elevated LDL in patients with hypercholesterolemia and mixed dyslipidaemia.

Expert opinion on pharmacotherapy·2026
Same author

Residual glucose metabolism and Long-Term clinical outcomes in multivessel coronary artery disease: A cohort study.

Endocrine·2026
Same author

Comparing rosuvastatin and atorvastatin on cardiovascular and kidney outcomes in patients with diabetes across chronic kidney disease stages: an emulated target trial in China.

EClinicalMedicine·2026
Same author

Targeting APOC3 with Olezarsen in Moderate Hypertriglyceridemia.

The New England journal of medicine·2025

Related Experiment Video

Updated: Nov 5, 2025

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
08:13

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

Published on: January 7, 2018

70.0K

Insulin resistance surrogates predict hypertension plus hyperuricemia.

Yaxin Li1,2,3, Aijun You1,2,3, Brian Tomlinson2,4

  • 1Shanghai Heart Failure Research Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

Journal of Diabetes Investigation
|May 13, 2021
PubMed
Summary

Four insulin resistance surrogates, including the glucose-triglyceride index (TyG index), TyG-BMI, TG/HDL-C, and METS-IR, are significantly associated with hypertension and hyperuricemia. TyG-BMI and METS-IR demonstrated moderate discriminative abilities for this comorbidity in older adults.

Keywords:
HypertensionHyperuricemiaInsulin resistance surrogates

More Related Videos

Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion
08:22

Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion

Published on: March 20, 2017

8.9K
Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
11:10

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice

Published on: November 16, 2011

95.1K

Related Experiment Videos

Last Updated: Nov 5, 2025

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
08:13

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

Published on: January 7, 2018

70.0K
Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion
08:22

Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion

Published on: March 20, 2017

8.9K
Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
11:10

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice

Published on: November 16, 2011

95.1K

Area of Science:

  • Gerontology
  • Metabolic Syndrome Research
  • Cardiovascular Epidemiology

Background:

  • Hypertension and hyperuricemia are prevalent conditions in older adults, often co-existing and increasing cardiovascular risk.
  • Insulin resistance is a key underlying mechanism implicated in both hypertension and hyperuricemia.
  • Several surrogate markers for insulin resistance have been developed and validated in various populations.

Purpose of the Study:

  • To compare the association of four insulin resistance surrogates with the comorbidity of hypertension plus hyperuricemia in individuals aged 65 years and older.
  • To evaluate the discriminative ability of these surrogates for identifying individuals with hypertension and hyperuricemia.

Main Methods:

  • A cross-sectional epidemiological study utilized data from a representative sample of 4,352 adults aged ≥65 years.
  • Four insulin resistance surrogates were calculated: glucose-triglyceride index (TyG index), TyG index with body mass index (TyG-BMI), triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C), and metabolic score for insulin resistance (METS-IR).
  • Multivariate logistic regression and receiver operating characteristic (ROC) analysis were employed to examine associations and discriminative abilities.

Main Results:

  • The study included 4,352 participants, with 587 (13.5%) having hypertension plus hyperuricemia.
  • All four insulin resistance surrogates (TyG index, TyG-BMI, TG/HDL-C, METS-IR) showed significant correlations with hyperuricemia, hypertension, and the combined condition.
  • The highest quartiles of all four indicators were associated with significantly increased odds of hypertension plus hyperuricemia, with odds ratios ranging from 6.39 to 9.30.
  • TyG-BMI and METS-IR exhibited moderate discriminative abilities for hypertension plus hyperuricemia, with AUC values of 0.72 and 0.73, respectively.

Conclusions:

  • The TyG index, TyG-BMI, TG/HDL-C, and METS-IR are all significantly associated with the presence of hypertension plus hyperuricemia in older adults.
  • TyG-BMI and METS-IR demonstrate potential as useful tools for discriminating individuals with this combined comorbidity.