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Bioreactance-derived haemodynamic parameters in the transitional phase in preterm neonates: a longitudinal study
Lizelle Van Wyk1, Johan Smith2, John Lawrenson3
1Division Neonatology, Dept. Pediatrics & Child Health, Stellenbosch University and Tygerberg Children's Hospital, Cape Town, South Africa. lizelle@sun.ac.za.
Journal of Clinical Monitoring and Computing
|May 13, 2021
Summary
This study monitored hemodynamics in preterm infants using bioreactance (BR), a non-invasive method. BR-derived variables showed significant associations with postnatal age in stable neonates during their first 72 hours.
Area of Science:
- Neonatal physiology
- Cardiovascular monitoring
- Medical technology
Background:
- Bioreactance (BR) offers non-invasive, continuous monitoring of hemodynamic variables.
- Understanding hemodynamic transitions in preterm infants is crucial for their care.
- Limited data exists on BR-derived hemodynamics in stable preterm neonates during early life.
Purpose of the Study:
- To determine reference values for BR-derived hemodynamic variables in stable preterm infants.
- To assess the association of these variables with postnatal age and clinical factors.
- To explore the utility of BR monitoring in the transitional period for neonates.
Main Methods:
- Prospective observational study of stable preterm infants (<37 weeks gestation).
- Continuous bioreactance monitoring for the first 72 hours of life.
- Data collected on heart rate, blood pressure, stroke volume, cardiac output, and total peripheral resistance index.
Main Results:
- Sixty-three preterm infants (mean GA 31 weeks) were enrolled.
- BR-derived hemodynamic parameters were significantly associated with postnatal age.
- Associations remained significant after correcting for gestational age, birth weight, and respiratory support.
Conclusions:
- This is the first study to present longitudinal BR-derived hemodynamic data in stable preterm infants during the first 72 hours.
- BR monitoring is a feasible non-invasive tool for assessing systemic blood flow in this population.
- BR may offer valuable insights into transitional neonatal physiology and pathophysiology.
