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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Related Experiment Video

Updated: Nov 5, 2025

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples
07:03

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Theranostics for Breast Cancer Stem Cells.

Woo Kyung Moon1, Hoe Suk Kim2

  • 1Department of Radiology, Seoul National University & Seoul National University Hospital, Seoul, Republic of Korea. moonwk@snu.ac.kr.

Advances in Experimental Medicine and Biology
|May 13, 2021
PubMed
Summary
This summary is machine-generated.

Identifying new biomarkers like extra domain-B fibronectin (EDB-FN) is crucial for targeting breast cancer stem cells (BCSCs). This review explores nanoparticle-based theranostics for effective BCSC treatment and monitoring.

Keywords:
Breast cancer stem cell (BCSC)Magnetic resonance imaging (MRI)TheranosticsThermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPION)extra domain-B fibronectin (EDB-FN)

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Area of Science:

  • Oncology
  • Nanotechnology
  • Biomolecular Imaging

Background:

  • Breast cancer stem cells (BCSCs) drive tumor development, metastasis, and recurrence, posing a significant clinical challenge.
  • Effective targeting of BCSCs requires specific biomarkers for differentiation from other tumor cells.
  • Molecular imaging and nanotechnology offer promising avenues for BCSC diagnosis and therapy.

Purpose of the Study:

  • To review the development of BCSC-targeted theranostics using nanoparticles.
  • To highlight the potential of extra domain-B fibronectin (EDB-FN) as a novel BCSC biomarker.
  • To discuss the application of EDB-FN-targeted nanoparticles for delivering therapeutic agents.

Main Methods:

  • Review of recent literature on BCSC targeting strategies.
  • Exploration of nanoparticle-based drug and siRNA delivery systems.
  • Focus on the use of peptides targeting the EDB-FN biomarker.

Main Results:

  • Extra domain-B fibronectin (EDB-FN) identified as a putative biomarker for BCSCs.
  • Nanoparticles conjugated with EDB-FN-specific peptides enable selective targeting of BCSCs.
  • Potential for image-guided diagnosis and therapy monitoring of BCSCs.

Conclusions:

  • Targeting BCSCs with EDB-FN biomarkers via nanotechnology presents a promising theranostic approach.
  • Nanoparticle-mediated delivery of siRNA or drugs offers a strategy for BCSC treatment.
  • Further research in BCSC-targeted theranostics is essential for clinical translation.