Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Development of a Fit-For-Purpose Multi-Marker Panel for Early Diagnosis of Pancreatic Ductal Adenocarcinoma.

Molecular & cellular proteomics : MCP·2024

Same author

Comparative profiling by data-independent acquisition mass spectrometry reveals featured plasma proteins in breast cancer: a pilot study.

Annals of surgical treatment and research·2024

Same author

Association Between the C4 Binding Protein Level and White Matter Integrity in Major Depressive Disorder.

Psychiatry investigation·2022

Same author

Novel Diagnostic Biomarkers for High-Grade Serous Ovarian Cancer Uncovered by Data-Independent Acquisition Mass Spectrometry.

Journal of proteome research·2022

Same author

Nogo-A regulates myogenesis via interacting with Filamin-C.

Cell death discovery·2021

Same author

Erratum: A Validation Study of a Multiple Reaction Monitoring-Based Proteomic Assay to Diagnose Breast Cancer.

Journal of breast cancer·2020

Search research articles

Related Experiment Video

Updated: Nov 5, 2025

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Published on: February 27, 2015

Proteomic Interrogation in Cancer Biomarker.

¹Core Protein Resources Center, Daegu Gyeongbuk Institute of Science and Technology, Daegu, South Korea. unbeom.kang@bertis.com.

Advances in Experimental Medicine and Biology

|May 13, 2021

Summary

Proteomics innovations enhance cancer biomarker discovery for improved diagnosis and treatment. Understanding clinical proteomics is crucial for translating research findings into patient care.

Keywords:

Biomarker Cancer Clinical application Proteogenomics Proteomics

More Related Videos

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools

Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools

Published on: August 19, 2025

Related Experiment Videos

Last Updated: Nov 5, 2025

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Published on: February 27, 2015

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools

Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools

Published on: August 19, 2025

Area of Science:

Proteomics
Biomarker Discovery
Cancer Research

Background:

Biomarkers are essential for cancer diagnosis and treatment.
Advancements in mass spectrometry and data processing drive proteomics innovation.
Clinical proteomics is increasingly applied to biological studies.

Purpose of the Study:

To discuss case research in clinical proteomics.
To provide an overview of current developments in proteomics-based cancer biomarker research.
To highlight the importance of appropriate biomarker development for clinical translation.

Main Methods:

Review of clinical proteomics techniques.
Analysis of protein identification in large patient cohorts.
Examination of quantitative data for biomarker development.

Main Results:

Proteomics techniques are adapted for protein identification and biomarker development.
Quantitative data aids in creating more sensitive and specific cancer screening methods.
Novel findings in proteomics-based cancer biomarker research are presented.

Conclusions:

Clinical proteomics offers significant potential for advancing cancer care.
Awareness of biomarker development challenges is vital for clinical application.
Further research facilitates the integration of useful biomarkers into clinical practice.