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Juan Pimentel1, Germán Zuluaga2, Elizabeth Borrero3

  • 1Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia. juan.pimentel@mail.mcgill.ca.

Salud Publica De Mexico
|May 13, 2021
PubMed
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Hospital administration of dipyrone was associated with increased mortality in severe dengue patients in Colombia. This finding suggests dipyrone should be avoided in dengue management due to safety concerns.

Area of Science:

  • Infectious Diseases
  • Clinical Epidemiology
  • Pharmacovigilance

Background:

  • Severe dengue poses a significant public health threat globally.
  • Identifying risk factors for mortality in severe dengue is crucial for improving patient outcomes.
  • Previous studies have explored various clinical and demographic factors associated with dengue mortality.

Purpose of the Study:

  • To identify demographic and clinical factors associated with severe dengue mortality.
  • To analyze risk factors in five Colombian departments between 2009 and 2013.
  • To inform clinical practice regarding medication use in severe dengue management.

Main Methods:

  • Secondary analysis of a case-control study.
  • Inclusion of patients admitted between 2009 and 2013.

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  • Utilized the Mantel-Haenszel procedure to identify associated factors.

    • Main Results:

    • Analysis included 58 cases (deaths) and 121 controls (survivors).
    • Four factors were significantly associated with mortality: hospital administration of dipyrone (aOR=6.38), presence of comorbidity (aOR=3.52), prior consultation for the same condition (aOR=3.99), and administration of acetaminophen (aOR=0.25).
    • Dipyrone administration was linked to a higher risk of mortality, while acetaminophen showed a protective association.

    Conclusions:

    • Hospital administration of dipyrone is associated with an increased risk of mortality in severe dengue patients.
    • Dipyrone has been withdrawn from markets in 20 countries due to adverse effects.
    • The use of dipyrone should be discouraged in the management of severe dengue.