Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

14.8K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
14.8K
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

147
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
147
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

183
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
183
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

9.8K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
9.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Microfluidic encapsulation of the human gut microbiota-a tool for research and beyond.

Microsystems & nanoengineering·2026
Same author

Prophage induction contributes to alterations in the gut phageome during intestinal inflammation.

Cell reports·2026
Same author

A meta-analysis of infant gut viromes reveals global patterns in bacteriophage community assembly and functional capacity over the first three years of life.

Nature communications·2026
Same author

Distinct associations among human milk microbiota and minerals in relation to early infant growth: a longitudinal study.

Journal of translational medicine·2026
Same author

Species-specific prophage induction by ciprofloxacin in human gut metagenomes.

bioRxiv : the preprint server for biology·2026
Same author

Real-world Genetic Testing Practices in Cardiomyopathy: National Insights From 1.7 Million Patients.

Journal of cardiac failure·2026
Same journal

Gut commensal Bacteroides-derived pantothenic acid alleviates metabolic syndrome.

Cell host & microbe·2026
Same journal

Predicting antimicrobial resistance for precision medicine.

Cell host & microbe·2026
Same journal

Meta-analysis reveals microbiome signatures for colorectal cancer that are universal across age groups and sequencing methods.

Cell host & microbe·2026
Same journal

Single-cell detection and quantification of the microbiota by MicFLY.

Cell host & microbe·2026
Same journal

Suppression of host salicylic acid defense by a phloem-colonizing pathogen effector in citrus Huanglongbing.

Cell host & microbe·2026
Same journal

CBASS limits bacteriophage production while maintaining cell viability in Pseudomonas aeruginosa.

Cell host & microbe·2026
See all related articles

Related Experiment Video

Updated: Nov 5, 2025

Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis
06:31

Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis

Published on: October 6, 2023

2.6K

A phingerprint for rheumatoid arthritis development?

Anshul Sinha1, Corinne F Maurice1

  • 1Department of Microbiology & Immunology, McGill University, Montreal, QC, Canada.

Cell Host & Microbe
|May 13, 2021
PubMed
Summary
This summary is machine-generated.

The human gut virome differs in individuals at risk for rheumatoid arthritis (RA). These findings suggest that bacteriophages may influence RA development and offer potential for new diagnostic biomarkers.

More Related Videos

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

503
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

616

Related Experiment Videos

Last Updated: Nov 5, 2025

Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis
06:31

Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis

Published on: October 6, 2023

2.6K
Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

503
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

616

Area of Science:

  • Microbiology
  • Immunology
  • Gastroenterology

Background:

  • The human gut microbiome, including viruses (virome), is increasingly linked to various health and disease states.
  • Rheumatoid arthritis (RA) is a chronic autoimmune disease with complex etiology.
  • Understanding the gut virome's role in RA pathogenesis is crucial for developing novel therapeutic and diagnostic strategies.

Purpose of the Study:

  • To investigate differences in the gut virome composition between individuals at risk for rheumatoid arthritis (RA) and healthy controls.
  • To explore the potential involvement of specific viral components, such as bacteriophages, in the development or progression of RA.
  • To identify potential viral biomarkers for early detection or risk assessment of RA.

Main Methods:

  • Metagenomic sequencing of fecal samples to characterize the gut virome.
  • Bioinformatic analysis to compare viral community structures between different subject groups.
  • Statistical analysis to identify significant differences in viral abundance and diversity.

Main Results:

  • Significant differences were observed in the gut virome composition of individuals at risk for RA compared to controls.
  • Specific types or abundances of bacteriophages were found to be altered in the at-risk group.
  • These viral alterations suggest a potential link between the gut virome and RA susceptibility.

Conclusions:

  • The gut virome, particularly bacteriophages, may play a role in the pathogenesis of rheumatoid arthritis.
  • Alterations in the gut virome could serve as potential biomarkers for identifying individuals at risk of developing RA.
  • Further research into the host-phage interactions in the gut is warranted for RA biomarker and therapeutic development.