Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Long-term Potentiation01:35

Long-term Potentiation

56.8K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
56.8K
Long-term Potentiation01:25

Long-term Potentiation

3.0K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
3.0K
Long-term Depression01:03

Long-term Depression

2.7K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
2.7K
Long-term Depression01:05

Long-term Depression

32.1K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
32.1K
Postsynaptic Potential (PSP)01:32

Postsynaptic Potential (PSP)

3.9K
Postsynaptic potential (PSP) refers to a change in the electrical potential of a neuron when neurotransmitters released by presynaptic neurons bind to postsynaptic receptors. This potential can either be excitatory, leading to depolarization and ultimately action potential generation, or inhibitory, leading to hyperpolarization and suppression of the postsynaptic neuron.
There are two types of receptors: ionotropic and metabotropic.
The ionotropic receptor is the membrane protein that has an...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: Spinal cord Tau pathology induces tactile deficits and cognitive impairment in Alzheimer's disease via dysregulation of CCK neurons.

Nature neuroscience·2026
Same author

Neuronal VPS13A depletion links diacylglycerol PKC signaling and synaptic spines.

BMC biology·2026
Same author

Human-specific multicopy gene FRMPD2 promotes synapse formation via recruitment of neuroligin 1.

bioRxiv : the preprint server for biology·2026
Same author

Functional Ca<sup>2+</sup>-permeable AMPA receptors in hippocampal astrocytes mediate calcium signaling in vitro.

Scientific reports·2026
Same author

Noninvasive tactile stimulation engaging a thalamic-amygdala circuit ameliorates mood dysfunction in mouse models of depression-like behavior.

Neuron·2026
Same author

Subthreshold membrane depolarization powerfully engages intracellular calcium dynamics in the brain.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Nov 5, 2025

Acquisition of a High-precision Skilled Forelimb Reaching Task in Rats
08:59

Acquisition of a High-precision Skilled Forelimb Reaching Task in Rats

Published on: June 22, 2015

10.6K

RTP801 regulates motor cortex synaptic transmission and learning.

Leticia Pérez-Sisqués1, Núria Martín-Flores1, Mercè Masana2

  • 1Department of Biomedicine, Faculty of Medicine, University of Barcelona, Catalonia, Spain; Institut de Neurociències, University of Barcelona, 08036, Catalonia, Spain.

Experimental Neurology
|May 13, 2021
PubMed
Summary

The stress-regulated protein RTP801 (also known as REDD1) contributes to neuronal death in neurodegenerative diseases. Its absence improves motor learning and synaptic function, suggesting a therapeutic target.

Keywords:
GluA1Motor learningPlasticityRTP801mTOR

More Related Videos

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity
11:56

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity

Published on: November 11, 2017

16.0K
Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function
07:47

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function

Published on: February 4, 2016

13.3K

Related Experiment Videos

Last Updated: Nov 5, 2025

Acquisition of a High-precision Skilled Forelimb Reaching Task in Rats
08:59

Acquisition of a High-precision Skilled Forelimb Reaching Task in Rats

Published on: June 22, 2015

10.6K
Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity
11:56

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity

Published on: November 11, 2017

16.0K
Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function
07:47

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function

Published on: February 4, 2016

13.3K

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Neurodegeneration

Background:

  • RTP801 (REDD1) is a stress-regulated protein implicated in neuronal death.
  • Upregulation of RTP801 is observed in Parkinson's and Huntington's diseases.
  • RTP801 knockdown improves motor deficits in disease models.

Purpose of the Study:

  • To investigate the physiological role of RTP801 in neuronal plasticity.
  • To determine RTP801's impact on motor learning.

Main Methods:

  • Investigated RTP801 presence in mammalian synapses (rat, mouse, human).
  • Utilized RTP801 knockout (KO) mice for experiments.
  • Analyzed synaptic transmission, spine density, and receptor levels (GluA1, TrkB) in motor cortex.

Main Results:

  • RTP801 is present in mammalian synapses.
  • Absence of RTP801 enhanced excitatory synaptic transmission.
  • RTP801 KO mice exhibited improved motor learning, altered spine morphology, and increased GluA1/TrkB receptor levels.

Conclusions:

  • RTP801 plays a significant role in modulating neuronal plasticity and motor learning.
  • Findings enhance understanding of RTP801's detrimental role in neurodegenerative disorders.